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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Large-conductance mechanosensitive channel ： ウィキペディア英語版 Large-conductance mechanosensitive channel Large-Conductance Mechanosensitive Channels (MscL) are pore-forming membrane proteins that are responsible for translating physical forces applied to cell membranes into electrophysiological activities. MscL has a relatively large conductance, 3-nS, making it permeable to ions, water, and small proteins when opened.〔 MscL acts as stretch-activated osmotic release valve in response to osmotic shock. ==History== MscL was first discovered on the surface of giant ''E. coli'' spheroplasts using patch-clamp technique. Subsequently, the Ec-MscL gene was cloned in 1994. Following the cloning of MscL, the crystal structure of Tb-MscL, EcoMscL's homolog in ''Mycobacterium tuberculosis'', was obtained in its closed conformation. In addition, the crystal structure of Sa-MscL and Ec-MscL have been determined using X-ray crystallography and molecular model respectively. However, some evidence suggests that the Sa-MscL structure is not physiological, and is due to the detergent used in crystallization. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Large-conductance mechanosensitive channel」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.